Incorrect. If you've actually played ME1's final battle you'd know any weapon that shoots Makos > Pulse Rifle.
I've finished both ME 1 and 2 twice. And you have no idea what you're on about.
I replied to your message with a loading screen picture of one of the mass relays scattered through the universe and you reply by saying "incorrect", what?
I have no idea what these "makos" are that are shot with weapons that you are talking about. I've only known one mako in the ME and that was the APC that the player used to drive around the maps.
Mass Relay, quoted from ME wiki which quoted it from the game:
Mass Relays are mass transit devices scattered throughout the galaxy, usually located within star systems. They form an enormous network allowing interstellar travel. Hailed as one of the greatest achievements of the extinct Protheans, a mass relay can transport starships instantaneously to another relay within the network, allowing for journeys that would otherwise take years or even decades with only FTL drives
Mass Relay is like a stargate, it has nothing to do with weapons.